This fundamental study substantially advances our understanding of the role of zinc in metabolism, specifically a newly established clinical link between mutations in the zinc transporter SLC39A5, ...

Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...

This valuable study combines experiments and theory to investigate the putative role of spontaneous correlated activity in establishing aligned topographic maps of neural activity in higher-order ...

This important study will allow for a better understanding of anthelmintic drug resistance in nematodes, a growing concern for public health. The authors provide a detailed analysis of the role of UBR ...

The paper introduces DeepTX, a valuable deep-learning framework linking stochastic, mechanistic modelling with single-cell RNA sequencing data to investigate transcriptional burst kinetics on a genome ...

Marcks and Marcks-like 1 proteins are required for normal neurite formation and proliferation of neuro-glial progenitors during development and regeneration of the Xenopus spinal cord implicating ...

The study provides valuable insights into the mechanisms underlying neurovascular coupling; the authors present solid evidence demonstrating that layer II/III pyramidal neurons can induce ...

This manuscript describes an important study of the giant virus Jyvaskylavirus. The characterisation presented is solid, although, in the current form, it is not clear to what extent these findings ...

Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells ...

However, technical and study bias affect the experimental procedures for detecting PPIs. For instance, cancer-associated proteins have received disproportional attention. Moreover, bait proteins in ...

Among these sensors, we further focused on the spatiotemporal dynamics of Rab10 and Rab4 activity during sLTP. We found that postsynaptic stimulation leads to the persistent inactivation of Rab10 and ...

This manuscript represents a fundamental contribution demonstrating that fentanyl-induced respiratory depression can be reversed with a peripherally-restricted mu opioid receptor antagonist. The paper ...