Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

De’Vondre Campbell has had his dreadlocks pulled multiple times in his nine-year career, but he never thought an opponent did ...

Hyde joins the Bills just in time for a playoff push but expects to take on a practice squad role in the regular season.

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

The Buffalo Bills stuck it to “the man” after their win over the San Francisco 49ers. The Bills (10-2) won in Week 13 over ...

Just when it seemed that San Francisco 49ers running back Christian McCaffrey was starting to find his rhythm, in a moment of ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

When Kyle Shanahan became head coach of the San Francisco 49ers in 2017, the team was in the midst of a rebuilding phase.

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...