Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...

San Francisco 49ers cornerback Deommodore Lenoir is set to return for Sunday's game against the Chicago Bears after missing ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

Superstar edge rusher Nick Bosa is officially ruled out for Sunday's contest against the Bears, according to ESPN's Adam ...

RB Christian McCaffrey looked to finally be taking off after his return from an Achilles injury but suffered a PCL injury ...

If there was ever a must-win scenario for the San Francisco 49ers, this week is it. The team has to get it done against the ...

More likely, the 49ers will end the season as the NFL’s most disappointing team. That’s where they are right now, and no one else is really close. They’re a victim of their own success, having gone to ...