With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

In the span of a week, the San Francisco 49ers are watching their running backs drop like flies. Superstar Christian ...

Head coach Kyle Shanahan and defensive coordinator Nick Sorensen shared injury updates on RB Isaac Guerendo, DL Nick Bosa and more and discussed how the team is preparing for a short turnaround ahead ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

More and more you could make an argument the most dangerous job is that of running back for the San Francisco 49ers.

Breaking down all of the good and some of the bad from the 49ers’ much-needed blowout win over the Bears in Week 14.

Moments after the conclusion of the game, a 44-42 thriller that ended with the Bills dropping only their third game of the ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...