National League Central rivals clash Monday, April 28, when the St. Louis Cardinals visit the Cincinnati Reds, with the first pitch set for 6:40 p.m. ET on MLB Network. The Cardinals have lost seven of their last 10 games coming into the first matchup of this four-game series,

Its Monday, April 28 and the Cardinals (12-16) are in Cincinnati to take on the Reds (15-13). Andre Pallante is slated to take the mound for St. Louis against Nick Martinez for Cincinnati. St. Louis comes to Ohio following a successful weekend at home against Milwaukee.

The Reds are favored (-124 on the moneyline to win) when they host the Cardinals (+104). The matchup on the mound for this contest is set with the Cincinnati Reds looking to Nick Martinez (0-3), and Andre Pallante (2-1) getting the nod for the St.

The Arizona Cardinals and the rest of the league wrapped up the 2025 NFL draft over the weekend. The Cardinals selected seven players, one in each of the seven rounds, and defense dominated. Six of their seven player selections were on defense.

ESPN's Mel Kiper didn't love the Cardinals' draft but didn't hate it. In his 2025 NFL draft grades, he gave them a B-plus. Kiper felt taking defensive lineman Walter Nolen 16th overall was a little high and is concerned about his consistency of play from down to down. However, he loved the pick of cornerback Will Johnson in the second round.

By Philip Pullella, Joshua McElwee and Crispian Balmer VATICAN CITY (Reuters) -Roman Catholic cardinals will begin their secret conclave to elect the new leader of the global Church on May 7, the Vatican said on Monday,

The cardinals set the date after arriving for the first day of informal meetings following Pope Francis’ funeral Saturday.

The ancient process for selecting a new leader for the Catholic Church is shrouded in secrecy, but a look at the people who will be making the decision may offer some clues into how they'll vote.

Nolan Arenado homered off Trevor Megill in the ninth inning, giving St. Louis a 6-5 win over the Milwaukee Brewers after the Cardinals wasted a five-run lead

Pregame analysis and predictions of the Milwaukee Brewers vs. St. Louis Cardinals MLB game to be played on April 27, 2025 on ESPN.