San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Wednesday practice report is starting to have two constants for the San Francisco 49ers. Those two constants are star players ...

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

See who's in and who's out for the Week 14 matchup between the San Francisco 49ers and Chicago Bears on December 8, 2024.

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

A year ago, 49ers head coach Kyle Shanahan conducted press conferences that mostly dealt with how to work in enough playing ...

Hufanga (wrist) was a limited participant at the 49ers' practice Wednesday. Hufanga was designated to return from injured reserve Wednesday, immediately participating in the team's first practice of ...