The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

San Francisco 49ers defensive end Nick Bosa (hip/oblique) missed his second contest in a row due to hip and oblique injuries.

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Josh Allen and the Buffalo Bills are on a roll and up next is a Rams team that can be dangerous. Here are some Bills Week 14 ...

For the past seven years, the Buffalo Bills had one of the best safety tandems in the league. Micah Hyde and Jordan Poyer, who both signed with Buffalo as free ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

ProFootballTalk founder Mike Florio has an intriguing idea for a change of scenery for Kyle Shanahan. Appearing on “The Rich ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.