Business Wire23d
VectorBuilder Powers FDA IND Approval of World’s First Umbilical Cord Blood-Derived Allogeneic CAR-T Product
The FDA IND approval of UC101 further showcases VectorBuilder’s mature platform of lentiviral manufacturing. In addition to its extensive FDA IND experience with transfection-based lentiviral ...
Frontiers6mon
Investigation of METTL3 as an inhibitor of kanamycin-induced ototoxicity via stress granule formation
Lentivirus-mediated transfection was employed to overexpress and knockdown METTL3 in HEI-OC1 cells. Knockdown of METTL3 resulted in increased reactive oxygen species (ROS) levels and apoptosis induced ...
Frontiers4y
Production of Vesicular Stomatitis Virus Glycoprotein-Pseudotyped Lentiviral Vector Is Enhanced by Ezrin Silencing
However, lentivirus vector generally do not express the accessory ... When VSV-G-bearing HIV-1 vector is constructed by transient transfection, its transduction titers are generally much higher than ...
Nature13y
Efficient transduction of healthy and malignant plasma cells by lentiviral vectors pseudotyped with measles virus glycoproteins
Usual lentiviral vectors (LVs) pseudotyped with vesicular stomatitis virus envelope glycoprotein poorly transduced healthy and malignant PCs. Here, we report that LVs pseudotyped with the ...