The FDA IND approval of UC101 further showcases VectorBuilder’s mature platform of lentiviral manufacturing. In addition to its extensive FDA IND experience with transfection-based lentiviral ...

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This article examines viral and non-viral vectors in gene therapy, highlighting their mechanisms, advantages, and limitations ...

541 671 CRISPR cell line (Transient transfection) (Extra order/on-target KO line) 221 274 CRISPR cell line (Lentiviral delivery) (1 ctrl line + 1 on-target KO line) 585 726 CRISPR cell line ...

Stable cell lines CD44v6 (CD44 variant isoform 6) or C1QBP (complement C1q binding protein) knockdown or overexpression was established using lentivirus transfection or gateway systems. A total of 142 ...

When C33a and SiHa cells reached 20–30% confluence on the day of transfection, two lentiviral stocks (named GV248-shKIF2C and GV248-shCon, purchased from Genechem, Shanghai, China) were transduced ...

Five different mouse CLASP1 and mouse CLASP2 shRNA lentiviral constructs (Mission, Sigma-Aldrich) were used in this study. A scramble shRNA construct was used as a control. Constructs were first ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...