The blaze was reported just before 8 p.m. Friday at 24 Rowell St. and drew about 30 firefighters from several departments.
No injuries were reported; the fire department says the American Red Cross is helping the two people displaced from the home.
A large fire in Leonia destroyed two buildings at a condominium complex and displaced more than 30 people. It started at 8:30 a.m. Friday, sending people running from their homes to flee the flames.