49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury during Sunday's 35-10 loss to the Buffalo Bills, and will be placed on injured reserve as result. McCaffrey's recovery is expected to be six weeks, meaning that the rest of his season is in jeopardy.

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve Tuesday a day after coach Kyle Shanahan indicated that both he and fellow running back Jordan Mason would go on IR after suffering injuries in the team’s Week 13 loss to the Buffalo Bills.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

The San Francisco 49ers entered this season with lofty aspirations. For the most part, their hopes have been dashed -- and the bottom may be in danger of falling out from under them. On Monday, the 49ers revealed the latest in a spate of injuries that have devastated the team this season.

Star running back Christian McCaffrey will miss the remainder of the regular season with a PCL injury sustained in the San Francisco 49ers' 35-10 loss to the Buffalo Bills on Sunday night.

San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season.

Among the NFL players who suffered injuries in Week 13, Baker Mayfield entered that unwanted mix. And Taysom Hill took a bad injury. But leading the high-profile way on the injury list, Christian McCaffrey and Trevor Lawrence both failed to finish their respective contests.