An illustration of the pain signaling pathway elicited by CGRP. CGRP activates the CGPR receptor on Schwann cells. The CGPR receptor traffics to endosomes, where sustained signaling results in the ...

These intracellular signaling pathways, also called signal transduction cascades, typically amplify the message, producing multiple intracellular signals for every one receptor that is bound.

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...