After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do ...

For decades, we’ve believed the bright redness of sunburn — along with its irritating sting and peeling skin — was the result ...

Since its discovery in the 1990s, programmed cell death protein 1 (PD-1) has been regarded as a leading target in cancer treatments. A checkpoint receptor that often resides on the surface of ...

Researchers have discovered that mouse PD-1 is significantly weaker than human PD-1, calling into question their reliability ...

Drugs that block cytotoxic T lymphocyte associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) activate the cancer-killing T cells that had ...

About LM-299 LM-299 is an investigational bispecific antibody targeting both programmed cell death protein-1 (PD-1) and vascular endothelial growth factor (VEGF). This innovative therapeutic ...

A novel molecular tool developed by a Lehigh University professor of biological sciences is enabling scientists to precisely ...

Spatial organization of proteins (dots) within a human cell: Each protein is placed according ... of proteins involved in a form of programmed cell death called ferroptosis led the researchers ...

BCL-2 inhibitors, such as venetoclax (Venclexta) work by targeting the BCL-2 protein, which plays a key role in preventing apoptosis, or programmed cell death. According to John Seymour, MD, ...

Studies of living participants and postmortem brains confirm that gene expansion is a promising target for HD prevention ...

After years of setbacks, treatments for acute stroke have finally emerged, including aspirin 1 ... neuronal cell death in the borderzone of ischemia. This process is mediated by programmed ...

Necroptosis, a pathway responsible for programmed ... death, necroptosis shares features of both apoptosis (natural cell breakdown) and necrosis (injury-related cell damage). Receptor-interacting ...