NFL Week 10 odds, picks, predictions, TV and streaming information for the Sunday football game between the Buffalo Bills and Indianapolis Colts.

The Buffalo Bills ride a four-game winning streak to Indianapolis on Sunday for a matchup with the 4-5 Colts. Here’s how you can watch, stream and listen to the game. Television The game’s on 4! The game will air locally on WIVB in the Buffalo market and on your local CBS

Buffalo has beaten Miami five straight times, including 31-10 in Week 2. Oddsmakers widely expect the Bills to continue that streak, with top sportsbooks such as FanDuel, DraftKings and Fanatics all listing them between 6- and 6.5-point home favorites.

The Bills have won three straight games and lead the second-place Dolphins by 3.5 games – the largest division lead in the NFL. Buffalo is also tied with the Houston Texans and Pittsburgh Steelers for the No. 2 seed in the AFC, 1.5 games behind the top-seeded Kansas City Chiefs.

The Indianapolis Colts are back at home in Week 10 to take on the Bills. So who is the early betting favorite, and by how much, in this game?

The Indianapolis Colts will have the tall task of attempting to snap their two-game losing streak by beating the 7-2 Buffalo Bills on Sunday. The game will be played at Lucas Oil Stadium and kickoff will be at 1:00 PM ET.

The "You Better You Bet" crew breaks down the best bets for the Week 10 matchup between the Bills and the Colts.