Columbia County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 52,589. The county seat is St. Helens. The Chinook and Clatskanie Native American peoples inhabited this region for centuries prior to the arrival of Robert Gray, captain of the ship Columbia Rediviva, in 1792. The Lewis and Clark Expedition tra…Columbia County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 52,589. The county seat is St. Helens. The Chinook and Clatskanie Native American peoples inhabited this region for centuries prior to the arrival of Robert Gray, captain of the ship Columbia Rediviva, in 1792. The Lewis and Clark Expedition traveled and camped along the Columbia River shore in the area later known as Columbia County in late 1805 and again on their return journey in early 1806.